Altered patterns of functional connectivity of posterior cingulate cortex on resting-state magnetic resonance imaging in children with attention-deficit or hyperactivity disorder

• Published in: Zhong hua yi xue za zhi Vol. 93; no. 24; p. 1881
• Main Authors: Yang, Shuo, Dong, Xuan, Wang, Su-hong, Wu, Ting, Ren, Yan-ling, Wang, Dan-dan, Tu, Wen-juan, Yi, Yang, Zheng, Ai-bin
• Format: Journal Article
• Language: Chinese
• Published: China 25.06.2013
• Subjects: Adolescent; Attention Deficit Disorder with Hyperactivity - physiopathology; Case-Control Studies; Child; Gyrus Cinguli - physiopathology; Humans; Magnetic Resonance Imaging; Neural Pathways
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2013.24.007

To explore the pathophysiological changes in the functional connectivity of posterior cingulate cortex (PCC) with other brain regions in children with attention-deficit or hyperactivity disorder (ADHD) on resting-state functional magnetic resonance imaging(fMRI) and explore the neural mechanisms of ADHD at the point of relationships between brain regions. Thirty children with ADHD from the Third Affiliated Hospital of Soochow University from June 2008 to April 2010 and another 30 age-and-gender-matched controls from a normal primary school over the same period underwent resting-state fMRI scans. And blood oxygenation level dependent (BOLD) signal was acquired to calculate the functional connectivity of PCC with other brain regions controls. Significant differences of connectivity between groups were analyzed with REST software. The pattern of functional connectivity of PCC for the ADHD group was similar to that of the control group. Significant positive functional connectivity with PCC was observed in the def