Superdisintegrants for solid dispersion: To produce rapidly disintegrating tenoxicam tablets via camphor sublimation

The authors examined the effects of three super-disintegrands (Kollidon CL, Ac-Di-sol, and Primojel) on the dissolution and absorption of tenoxicam from solid-dispersion formulations. The Primojel formulation had the highest drug absorption level, which was improved by tableting via camphor sublimat...

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Bibliographic Details
Published inPharmaceutical Technology Vol. 29; no. 1; pp. 68 - 78
Main Authors ALY, Adel M, SEMREEN, M, QATO, Mazen K
Format Magazine Article Trade Publication Article
LanguageEnglish
Published Duluth, MN Advanstar Communications 2005
MultiMedia Healthcare Inc
Subjects
Biological and medical sciences
Dispersion
Drug dosages
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology
Pharmacology. Drug treatments
Ratios
Standard deviation
Statistical data
Studies
Prostaglandin-endoperoxide synthase
Tenoxicam
Oxicam derivatives
Pharmaceutical technology
Enzyme
Enzyme inhibitor
Solid dispersion
Non steroidal antiinflammatory agent
Analgesic
Camphor
Dosage form
Antipyretic
Tablet
Oxidoreductases
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Summary:The authors examined the effects of three super-disintegrands (Kollidon CL, Ac-Di-sol, and Primojel) on the dissolution and absorption of tenoxicam from solid-dispersion formulations. The Primojel formulation had the highest drug absorption level, which was improved by tableting via camphor sublimation.
ISSN:1543-2521
2150-7376