EFFECT OF CITOFLAVIN ON THE PARAMETERS OF LIPID PEROXIDATION IN BLOOD PLASMA OF RATS UNDER COLD STRESS CONDITIONS.

• Published in: Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 79; no. 7; p. 29
• Main Authors: Dorovskikh, V A, Li, O N, Simonova, N V, Shtarberg, M A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2016
• Subjects: Animals; Cold-Shock Response - drug effects; Drug Combinations; Flavin Mononucleotide - pharmacology; Hypothermia - drug therapy; Hypothermia - metabolism; Inosine Diphosphate - pharmacology; Lipid Peroxidation - drug effects; Male; Niacinamide - pharmacology; Rats; Succinates - pharmacology
• ISSN: 0869-2092
• DOI: 10.30906/0869-2092-2016-79-7-29-34

The possibility of correcting free radical oxidation of lipid membranes by the administration of cytoflavin was experimentally studied in rats. It is established that daily cold exposure for 3 h leads to increase in the level of lipid hydroperoxides, diene conjugates, and malonic dialdehyde on the background of decrease in activity of the antioxidant system in the blood of experimental animals. The introduction of cytoflavin (100 mg/kg, i.p.) for 21 day immediately prior to cold exposure leads to reliable (p < 0.05) decrease in the blood level of lipid hydroperoxides (by 13 - 21%), diene conjugates (by 24 - 25%), and malonic dialdehyde (by 20 - 33%) in comparison to rats of the control group. Analysis of the effect of cytoflavin on activity of the antioxidant system components showed that the level of ceruloplasmin and vitamin E in the blood of animals was reliably (p < 0.05) higher by 10 - 33% than analogous indicator in rats of the control group. Thus, the application of cytoflavin under conditions of long-term influence of cold on the organism of animals leads to stabilization of the processes of lipid peroxidation on the background of increased activity of the blood antioxidant system.