Effect of Dingguier umbilical paste on rats with functional dyspepsia and mice with splenic asthenia

• Published in: Zhongguo zhongyao zazhi Vol. 38; no. 7; p. 1067
• Main Authors: Ma, Jian-Li, Zhao, Si-Jun, Wang, Ting-Ting, Piao, Jin-Hua, Li, Xiang, Gao, Lei, Wang, Xiao-Qing
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2013
• Subjects: Animals; Asthenia - drug therapy; Asthenia - pathology; Asthenia - physiopathology; Body Weight - drug effects; Drugs, Chinese Herbal - administration & dosage; Dyspepsia - drug therapy; Dyspepsia - physiopathology; Eating - drug effects; Female; Gastric Emptying - drug effects; Humans; Male; Mice; Rats; Rats, Wistar; Spleen - drug effects; Spleen - pathology; Umbilicus
• ISSN: 1001-5302
• DOI: 10.4268/cjcmm20130728

To observe the effect of Dingguier umbilical paste on rats with functional dyspepsia and mice with splenic asthenia, and investigate the related mechanism. Functional dyspepsia models of rats were made by irregular food intake plus diluted hydrochloric acid. Successional treatments were offered for 14 days. The rats weights, contents of serum NO, AChE and MC were measured. The rats with splenic asthenia were made by rhubarb feed, and observed the affection of gastric emptying. Compared with those in the model control group, the weight of rats in all dosages Dingguier umbilical paste groups increased obviously (P < 0.05), pepsin activity of rats in the dosage (1.34 g x kg(-1)) Dingguier umbilical paste groups was significantly higher and the contents of NO and quantities of MC in the dosage (2.67 g x kg(-1)) Dingguier umbilical paste groups decreased clearly (P < 0.05), and the contents of serum AChE in all dosages Dingguier umbilical paste groups rose apparently. The weight of mice with splenic asthenia incre