The special role of inducible NO-synthase in the mechanism of rat coronary vessels tone regulation during immobilization stress, combined with diabetes mellitus

Persistent hyperglycemia after intraperitoneal injection of streptozocin (50 mg/kg) to the rats prevents decrease of coronary vessels myogenic tone and myocardial contractility during subsequent 6-hr immobilization stress. The intensity of these abnormalities in all experimental groups is significan...

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Published inRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 100; no. 4; p. 433
Main Authors Lazuko, S S, Beliaeva, L E, Solodkov, A P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.04.2014
Subjects
Animals
Coronary Vessels - enzymology
Coronary Vessels - pathology
Coronary Vessels - physiopathology
Diabetes Mellitus, Experimental - enzymology
Diabetes Mellitus, Experimental - pathology
Diabetes Mellitus, Experimental - physiopathology
Enzyme Inhibitors - pharmacology
Female
Immobilization
Isothiuronium - analogs & derivatives
Isothiuronium - pharmacology
Muscle Tonus
Muscle, Smooth, Vascular - enzymology
Muscle, Smooth, Vascular - physiopathology
Myocardium - enzymology
Myocardium - pathology
Nitric Oxide - metabolism
Nitric Oxide Synthase Type II - antagonists & inhibitors
Nitric Oxide Synthase Type II - biosynthesis
Rats
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Summary:Persistent hyperglycemia after intraperitoneal injection of streptozocin (50 mg/kg) to the rats prevents decrease of coronary vessels myogenic tone and myocardial contractility during subsequent 6-hr immobilization stress. The intensity of these abnormalities in all experimental groups is significantly reduced with the supplement of the perfusate with inducible NO-synthase (iNOS) selective blocker S-methylisothiourea. Similar rise of the NO2-/NO3- concentration in the rats' blood after "stress", "diabetes mellitus" and "diabetes mellitus + stress" combines with an increase of iNOS transcripts in the myocardium to 6, 5.8 and 51 times compared with control. These data testify to a substantial modification of the cells from coronary vessels in the presence of marked and persistent hyperglycemia. Inducible NO-synthase uncoupling caused by excessive formation of the reactive oxygen and nitrogen species in the myocardium may be one of number mechanisms responsible for such phenotypic vascular alteration in the "stress + diabetes mellitus" group.
ISSN:0869-8139