The impact of HLA high resolution typing mismatching of donor-recipient pairs on outcome of unrelated donor hematopoietic stem cell transplantation

• Published in: Zhōnghuá xuèyèxué zázhì Vol. 33; no. 5; p. 353
• Main Authors: He, Jun, Xu, Chao, Wu, Xiao-jin, Bao, Xiao-jing, Qiu, Qiao-cheng, Yuan, Xiao-ni, Li, Yang, Shen, Hong-jie, Wu, De-pei, Hong, Jun-ling, Liu, Jing-Hu, DU, Hai-ying, Zhang, Lei, DU, Dan, Lu, Jing, Liu, Jing
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2012
• Subjects: Hematopoietic Stem Cell Transplantation; Histocompatibility Testing; HLA Antigens - genetics; HLA Antigens - immunology; Humans; Leukemia, Myeloid, Acute - immunology; Leukemia, Myeloid, Acute - surgery; Lymphoma, Non-Hodgkin - immunology; Lymphoma, Non-Hodgkin - surgery; Myelodysplastic Syndromes - immunology; Myelodysplastic Syndromes - surgery; Prognosis; Retrospective Studies; Unrelated Donors
• ISSN: 0253-2727

To study the impact of various human leukocyte antigen (HLA) high resolution typing mismatching of donor-recipient pairs on prognosis of unrelated donor hematopoietic stem cell transplantation. 835 donor-recipient pairs of CMDP data from 2005 to 2010 were analyzed retrospectively. HLA-A, B, C, DRB1 and DQB1 typing were performed using SBT, SSOP and SSP methods. The diseases involved in acute myeloid leukemia (AML) (n = 288), acute lymphoid leukemia (ALL) (n = 227), chronic myeloid leukemia (CML) (n = 187), myelodysplastic syndrome (MDS) (n = 52), non-hodgkin's lymphoma(NHL) (n = 25), aplastic anemia(AA) (n = 42) and thalassemia (n = 14). Of 835 donor-recipient pairs, 362 were completely matched, 159 had a mismatch for a single allele, 125 had a mismatch for a single antigen, 95 had mismatched for both single allele and single antigen, 29 were mismatched at double allele, 20 at double antigen, 45 at multiple allele and antigen. The follow-up assessment was completed before March 2011. HLA-matched pairs had hig