An evaluation of plasma aldosterone-to-active-renin ratio in different postures in combination with aldosterone concentration in the diagnosis of aldosteronoma

• Published in: Chung-hua nei kʿo tsa chih Vol. 55; no. 6; p. 451
• Main Authors: Zhu, J, Jin, N, Zang, L, Gu, W J, Yang, G Q, Yang, L J, Guo, Q H, Wang, X L, Lyu, Z H, Ba, J M, Dou, J T, Mu, Y M
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2016
• Subjects: Aldosterone - blood; Asian Continental Ancestry Group; China; Essential Hypertension; Humans; Hyperaldosteronism - blood; Hyperaldosteronism - diagnosis; Hyperaldosteronism - ethnology; Hypertension - blood; Hypertension - etiology; Posture; Predictive Value of Tests; Renin - blood; ROC Curve; Sensitivity and Specificity; China
• ISSN: 0578-1426
• DOI: 10.3760/cma.j.issn.0578-1426.2016.06.010

To investigate the diagnostic value of plasma aldosterone-to-active-renin ratio(ARR)in combination with plasma aldosterone concentration(PAC)in the predication of aldosteronoma(APA). A total of 85 APA and 155 essential hypertension(EH)patients from January 2012 to December 2014 in Chinese PLA General Hospital were enrolled. The ROC curve was applied to calculate the optimal cut-off points of ARR for APA. (1)The optimal cut-off point of supine ARR was 1 707.4(pmol/L)/(μg·L(-1)·h(-1))[61.64(ng/dl)/(μg·L(-1)·h(-1))] with the sensitivity, specificity and accuracy of 89.41%, 80.65% and 83.75%, respectively. The specificity and accuracy of the diagnostic value for APA increased (89.03% and 87.5% respectively) when supine ARR cut-off point were used in combination with supine PAC over 329.4 pmol/L. (2) The optimal cut-off point of upright ARR was 741.5 (pmol/L)/(μg·L(-1)·h(-1))[26.77(ng/dl)/(μg·L(-1)·h(-1) )]with the sensitivity, specificity and accuracy of 85.88%, 91.61% and 89.58%, respectively. Similarly, the spe