Significance of PAX5 deletion in childhood B-lineage acute lymphoblastic leukemia without reproducible chromosomal abnormalities

• Published in: Zhongguo dang dai er ke za zhi Vol. 18; no. 4; p. 287
• Main Authors: Liu, Xiao-Ming, Zhang, Li, Ruan, Min, Liu, Tian-Feng, Zhang, Jia-Yuan, Liu, Fang, Qi, Ben-Quan, Chen, Xiao-Juan, Wang, Shu-Chun, Yang, Wen-Yu, Guo, Ye, Zou, Yao, Chen, Yu-Mei, Zhu, Xiao-Fan
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2016
• Subjects: Acute Disease; Adolescent; Cell Lineage; Child; Child, Preschool; Chromosome Aberrations; Disease-Free Survival; Female; Gene Deletion; Humans; Infant; Male; PAX5 Transcription Factor - genetics; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality
• ISSN: 1008-8830
• DOI: 10.7499/j.issn.1008-8830.2016.04.001

To identify the incidence of PAX5 deletion in childhood B-lineage acute lymphoblastic leukemia (B-ALL) without reproducible chromosomal abnormalities and to investigate the association between PAX5 abnormalities and prognosis of ALL. Multiplex ligation-dependent probe amplification was used to determine the copy numbers of PAX5 gene in children newly diagnosed with B-ALL without reproducible chromosomal abnormalities between April 2008 and April 2013 and controls (children with non-hematologic diseases or tumors). The patients were classifiied into deletion group and non-deletion group based on the presence of PAX5 deletion. Eighteen (21%) out of 86 children with B-ALL had PAX5 deletion. The deletion group had a significantly higher total white blood cell count at diagnosis than the non-deletion group (P=0.001). The Kaplan-Meier analysis demonstrated that the deletion group had a significantly lower disease-free survival (DFS) rate than the non-deletion group (0.69±0.12 vs 0.90±0.04; P=0.017), but there was n