Clinical study on risk factor associated with gut flora change in patients with rectal cancer during perioperative period

To investigate the effects of the different treatment on gut flora in patients with rectal cancer in the perioperative period. A total of 64 patients with rectal cancer were prospectively enrolled from July 2010 to June 2011 at the Qingdao University Medical College Affiliated Hospital, and randomiz...

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Bibliographic Details
Published inZhonghua wei chang wai ke za zhi Vol. 15; no. 6; p. 570
Main Authors Wang, Song, Wang, Mao-long, Li, Yu, Zhou, Yan-bing, Wang, Dong-sheng
Format Journal Article
LanguageChinese
Published China 01.06.2012
Subjects
Feces - microbiology
Humans
Microbiota
Perioperative Care - adverse effects
Prospective Studies
Rectal Neoplasms - microbiology
Rectal Neoplasms - surgery
Risk Factors
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Summary:To investigate the effects of the different treatment on gut flora in patients with rectal cancer in the perioperative period. A total of 64 patients with rectal cancer were prospectively enrolled from July 2010 to June 2011 at the Qingdao University Medical College Affiliated Hospital, and randomized into 8 groups receiving different treatments in perioperative period. Factorial design was used to study three factors including preoperative bowel preparation, antibiotics use, and postoperative fasting. Patients were randomized into 8 groups with 8 patients in each group using the random digit table. Preoperative and postoperative stool specimens were collected and diluted, which were transferred to selective medium. Bacteria counts were calculated after 48 hours of culture under constant temperature. The changes in gut flora between the different groups were compared. Compared to the preoperative parameters, total bacteria, Bifidobacterium, Peptostreptococcus, Lactobacillus, Bacteroides, Enterococcus decrease
ISSN:1671-0274