A Case of Advanced Esophageal Cancer Successfully Treated with Multidisciplinary Therapy

We report a case of advanced esophageal cancer that was successfully treated using chemotherapy, operation, and chemoradiotherapy. A 66-year-old man with advanced esophageal cancer(Mt, O-Is, T4[N0.7-stomach], N2, M0, Stage III)was administered chemotherapy(docetaxel[DOC], cisplatin[CDDP], and 5-fluo...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 45; no. 4; p. 703
Main Authors Kawada, Junji, Nishino, Masaya, Hata, Tomoki, Ogino, Takayuki, Okawa, Masateru, Hoshino, Hiromitsu, Okano, Miho, Nagai, Kenichi, Kakita, Naruyasu, Kim, Yongkook, Okuyama, Masaki, Tsujinaka, Toshimasa
Format Journal Article
LanguageJapanese
Published Japan 01.04.2018
Subjects
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Combined Modality Therapy
Esophageal Neoplasms - pathology
Esophageal Neoplasms - therapy
Humans
Lymphatic Metastasis
Male
Neoplasm Invasiveness
Treatment Outcome
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Summary:We report a case of advanced esophageal cancer that was successfully treated using chemotherapy, operation, and chemoradiotherapy. A 66-year-old man with advanced esophageal cancer(Mt, O-Is, T4[N0.7-stomach], N2, M0, Stage III)was administered chemotherapy(docetaxel[DOC], cisplatin[CDDP], and 5-fluorouracil[5-FU]: DCF). As the esophageal tumor achieved complete clinical response after 2 courses of chemotherapy, lymph node dissection and proximal gastrectomy were performed for the residual tumor. Abdominal CT 3 months after surgery revealed lymph node swelling. He was diagnosed with lymph node metastasis and was administered chemoradiotherapy. After chemoradiotherapy, liver metastasis was revealed, and he underwent immune checkpoint inhibitor immunotherapy. Despite the administration of immune checkpoint inhibitors, the liver metastasis developed, so he was treated with S-1 chemotherapy. S-1 chemotherapy resulted in a favorable response, and almost all metastatic lesions decreased. The patient is alive 12 months after S-1 chemotherapy without any signs of tumor regrowth.
ISSN:0385-0684