The antagonistic effect of folic acid and resveratrol on cleft palate in mice induced by TCDD

• Published in: Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery Vol. 29; no. 3; p. 197
• Main Authors: He, Xiao-Meng, Liu, Cui-Ping, Gan, Li-Qiang, Yuan, Xin-Gang, Qiu, Lin, Tian, Xiao-Fei, Liu, Yan, Xiao, Jun, Wei, Guang-Hui, Fu, Yue-Xian
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2013
• Subjects: Abnormalities, Drug-Induced - prevention & control; Animals; Cleft Palate - chemically induced; Cleft Palate - prevention & control; Female; Fetus; Folic Acid - administration & dosage; Folic Acid - pharmacology; Humans; Mice; Mice, Inbred C57BL; Polychlorinated Dibenzodioxins - antagonists & inhibitors; Pregnancy; Random Allocation; Stilbenes - administration & dosage; Stilbenes - pharmacology; Teratogens
• ISSN: 1009-4598

To evaluate whether or not administration of folic acid and resveratrol have preventive effects on cleft palate formation as well as the comparison of the two drugs' s effects. Pregnant mice were randomly divided into 9 groups, with 8 mice in each group. The TCDD group mice were dosed with TCDD 28 microg/kg body weight on gestation day 10 (GD 10) animals in folic acid group were respectively dosed with folic acid 15, 10, 5 mg/kg and TCDD 28 microg/kg; resveratrol treated mice were divided into 3 groups: resveratrol 50 mg/kg were orally administered for 6 consecutive days, from gestational day GD 8 to GD13 in resveratrol (GD8-13 ) group; resveratrol 50 mg/kg were orally administered for 6 consecutive days, from gestational day GD 8 to GD13, followed hy an oral administered with TCDD on GD10 in resveratrol (GD8-13) + TCDD group; resveratrol 50mg/kg and TCDD 28 microg/kg were used by gavage administration at GD10 in resveratrol (GD10) + TCDD group. Control mice were treated with the same volume of water for 6 co