Effects of androgens on the long-term depression of HVC-RA pathway in adult male zebra finches

Androgens can affect the singing behavior via regulating the song control system. In the present study, the effect of androgen on the synaptic plasticity of high vocal center (HVC)-robust nucleus of the arcopallium (RA) pathway was investigated through electrophysiological recording in vivo. We divi...

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Bibliographic Details
Published inSheng li hsüeh pao Vol. 69; no. 4; p. 397
Main Authors Zhang, Nan, Wang, Song-Hua, Meng, Wei, Li, Dong-Feng
Format Journal Article
LanguageChinese
Published China 25.08.2017
Subjects
Androgens - physiology
Animals
Electrophysiological Phenomena
Finches - physiology
High Vocal Center - physiology
Male
Neuronal Plasticity
Testosterone
Vocalization, Animal
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Summary:Androgens can affect the singing behavior via regulating the song control system. In the present study, the effect of androgen on the synaptic plasticity of high vocal center (HVC)-robust nucleus of the arcopallium (RA) pathway was investigated through electrophysiological recording in vivo. We divided the adult male zebra finches into control, castration and castration plus testosterone implantation groups. The changes of long-term depression (LTD) and the paired-pulse facilitation in HVC-RA pathway induced by high-frequency (400 Hz, 2 s) stimulation of HVC were recorded, respectively. The results showed that high-frequency stimulation could effectively induce LTD in control group, but only evoke short-term depression in the castration group. In castration plus testosterone implantation group, LTD was restored. The paired-pulse facilitation was not obvious in the castration group, whereas it was significantly improved in the control and castration plus testosterone implantation groups. These results suggest
ISSN:0371-0874