Associations of signal transducer and activators of transcription 3 polymorphism with the susceptibility to hepatitis B virus-related hepatocellular carcinoma

To evaluate the association of signal transducer and activators of transcription 3 (STAT3) -1096G/C polymorphism in promoter region with the susceptibility to HBsAg positive hepatocellular carcinoma (HCC). A total of 632 patients with HCC and 723 HBV-infected subjects without HCC treated at Changhai...

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Published inZhōnghuá yùfáng-yīxué zázhì Vol. 48; no. 6; p. 517
Main Authors Xie, Jiaxin, Gao, Qiuju, Yang, Dan, Liu, Tianpeng, Cao, Guangwen
Format Journal Article
LanguageChinese
Published China 01.06.2014
Subjects
Aged
Alleles
Carcinoma, Hepatocellular
Case-Control Studies
China
Disease Susceptibility
Female
Genetic Predisposition to Disease
Genotype
Hepatitis B
Hepatitis B virus
Humans
Liver Neoplasms
Male
Odds Ratio
Polymorphism, Genetic
Polymorphism, Single Nucleotide
China
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Summary:To evaluate the association of signal transducer and activators of transcription 3 (STAT3) -1096G/C polymorphism in promoter region with the susceptibility to HBsAg positive hepatocellular carcinoma (HCC). A total of 632 patients with HCC and 723 HBV-infected subjects without HCC treated at Changhai Hospital of Shanghai from 2009 to 2012 were included in this case-control study. The polymorphism of STAT3 -1096 G/C was genotyped by Fluorescent probe-Real time quantitative PCR. Univariate analysis was used to calculate the odds ratio (OR) and its 95% confidence interval (CI). The frequency of genetic allele STAT3 -1096G/C (GC+CC) of control group and case group were 61.83% (447/723) and 60.60% (383/632), while difference of HCC risk was not found among different genotypes (OR = 0.95, 95%CI: 0.76-1.18). When stratified by sex, the frequency of genetic allele STAT3 -1096C (GC+CC) of control group and case group were 62.18% (314/505) and 61.75% (331/536) in men, 61.01% (133/218) and 54.17% (52/96) in women, respec
ISSN:0253-9624