Diagnostic value of radom spot albuminuria to creatinine ratio in women with preeclampsia

• Published in: Chung-hua fu chʿan kʿo tsa chih Vol. 47; no. 3; p. 166
• Main Authors: Gao, Yun-fei, Huang, Qi-tao, Zhong, Mei, Wang, Yan, Wang, Wei, Wang, Zhi-jian, Leng, Ling-zhi, Yu, Yan-hong
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2012
• Subjects: Adult; Albumins - analysis; Albuminuria - diagnosis; Albuminuria - urine; Biomarkers - blood; Biomarkers - urine; Creatinine - blood; Creatinine - urine; Female; Humans; Pre-Eclampsia - blood; Pre-Eclampsia - diagnosis; Pre-Eclampsia - pathology; Pre-Eclampsia - urine; Predictive Value of Tests; Pregnancy; ROC Curve; Sensitivity and Specificity; Severity of Illness Index; Uric Acid - blood; Urinalysis - methods
• ISSN: 0529-567X

To investigate the correlation between spot albuminuria to creatinine ratio (ACR) and 24 h urinary protein excretion in women with preeclampsia and determine the optimal cut-off values of spot ACR in mild preeclampsia and severe preeclampsia. Twenty-eight women with mild preeclampsia and 22 with severe preeclampsia at Nanfang Hospital, Southern Medical University between October 2010 and June 2011 were recruited. Maternal serum cystatin, uric acid, urea nitrogen, creatinine and albumin levels were collected and analyzed. Twenty-four hours urinary protein excretion was measured with immunoturbidimetric assay and ACR with automatic analyzer DCA2000. The correlation between ACR and 24 hours urinary protein excretion was explored. And the optimal cut-off values of the spot ACR for mild and severe preeclampsia were determined with receiver operating characteristic curve. (1) Maternal serum biochemical parameters: uric acid levels in mild and severe preeclampsia were (359 ± 114) µmol/L and (450 ± 132) µmol/L, while