Acidophil stem cell pituitary neuroendocrine tumors/adenoma: a clinicopathological analysis of five cases

• Published in: Zhonghua bing li xue za zhi Vol. 53; no. 5; p. 446
• Main Authors: Lou, L, Du, S X, Fu, Y T, Shao, Q Q, Guo, W L, Zong, Y P, Qin, M M, Tian, X X, Li, Y H
• Format: Journal Article
• Language: Chinese
• Published: China 08.05.2024
• Subjects: Adenoma - metabolism; Adenoma - pathology; Adult; Aged; Female; Humans; Immunohistochemistry; Male; Middle Aged; Neuroendocrine Tumors - metabolism; Neuroendocrine Tumors - pathology; Neuroendocrine Tumors - surgery; Pituitary Neoplasms - metabolism; Pituitary Neoplasms - pathology; Prolactin - metabolism; Young Adult
• ISSN: 0529-5807
• DOI: 10.3760/cma.j.cn112151-20231019-00275

To investigate the clinicopathological characteristics of acidophil stem cell pituitary neuroendocrine tumors (PitNET)/adenoma. Five cases of acidophil stem cell PitNET/adenoma were diagnosed between May 2022 and July 2023 at the Second Hospital of Hebei Medical University, Shijiazhuang, China. The clinicopathological features of the tumor were analyzed by using histology, immunohistochemistry, and electron microscopy. The relevant literature was reviewed. There were 1 male and 4 females, aged from 23 to 69 years. Patient 3 was 55 years old at the time of diagnosis and first surgery, and relapsed 5 years later. The patients' median age was 32 years. Patients 1 and 5 showed elevated blood prolactin, with various degrees of hormonal symptoms except Patient 3, who showed only tumor compression symptoms. Imaging studies showed that all cases involved the sellar floor. The tumors of Patients 1, 2 and 5 were closely related to the cavernous sinus segment of the internal carotid artery. The tumors exhibited a diffus