Significance of preoperative neutrophil-to-lymphocyte ratio as a predictor of prognosis in patients with stage IV colorectal cancer

This study aimed to investigate the clinical significance of preoperative neutrophil-to-lymphocyte ratio(NLR)as a predictor of prognosis in patients with Stage IV colorectal cancer. A total of 130 patients who underwent operation for Stage IV colorectal cancer were enrolled in the study. Of the pati...

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Published inGan to kagaku ryoho Vol. 40; no. 12; p. 1603
Main Authors Shibutani, Masatsune, Maeda, Kiyoshi, Nagahara, Hisashi, Noda, Eiji, Ohtani, Hiroshi, Sugano, Kenji, Takii, Mamiko, Kimura, Kenjiro, Toyokawa, Takahiro, Amano, Ryosuke, Kubo, Naoshi, Tanaka, Hiroaki, Muguruma, Kazuya, Ohira, Masaichi, Hirakawa, Kosei
Format Journal Article
LanguageJapanese
Published Japan 01.11.2013
Subjects
Adult
Aged
Aged, 80 and over
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - surgery
Female
Humans
Leukocyte Count
Lymphocytes - cytology
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Neutrophils - cytology
Prognosis
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Summary:This study aimed to investigate the clinical significance of preoperative neutrophil-to-lymphocyte ratio(NLR)as a predictor of prognosis in patients with Stage IV colorectal cancer. A total of 130 patients who underwent operation for Stage IV colorectal cancer were enrolled in the study. Of the patients, 69 had an NLR of ≥ 3.0 and were defined as the high-NLR group. Patients who received preoperative therapy and underwent emergency operation for perforation were excluded from the analysis. The 2-year survival rate was 58.1% in the high-NLR group and 43.5% in the low-NLR group. The median survival time was 38.0 months in the high-NLR group and 22.3 months in the low-NLR group. The patient prognosis in the high-NLR group was significantly worse than that in the low-NLR group. A univariate analysis indicated that high NLR, peritoneal dissemination, curability C, histological type( non-differentiated), and number of organs involved in metastasis (more than 1 organ) were the risk factors of poor survival. All of these factors, except peritoneal dissemination, were independent risk factors for poor survival on multivariate analysis. A high preoperative NLR may be considered as a convenient biomarker to identify patients with a poor prognosis after operation for stage IV colorectal cancer.
ISSN:0385-0684