Efficacy of pathogenetic therapy in patients with acute gastrointestinal infections using succinic acid derivatives (reamberin)

• Published in: Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 76; no. 1; p. 11
• Main Authors: Tikhonova, E O, Liapina, E P, Shul'diakov, A A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2013
• Subjects: Acute Disease; Adolescent; Adult; Antioxidants - pharmacology; Antioxidants - therapeutic use; Bacterial Infections - blood; Bacterial Infections - drug therapy; Bacterial Infections - microbiology; Blood Platelets - drug effects; Endotoxins - antagonists & inhibitors; Endotoxins - blood; Female; Gastrointestinal Tract - drug effects; Gastrointestinal Tract - microbiology; Humans; Leukocytes - drug effects; Male; Meglumine - analogs & derivatives; Meglumine - pharmacology; Meglumine - therapeutic use; Middle Aged; Platelet Aggregation - drug effects; Succinates - pharmacology; Succinates - therapeutic use; Treatment Outcome
• ISSN: 0869-2092

Comparative study of efficacy of the official therapy of acute gastro-intestinal infections (65 patients) and a complex therapy using a succinic acid derivative reamberin (71 patients) has been carried out. It is established that the introduction of reamberin into infusion therapy in patients with acute gastro-intestinal infections leads to a faster reduction of basic symptoms of intoxication and gastroenteritis, normalization of leukocyte intoxication index, and correction of basic indices of thrombocytes aggregation. These results allow reamberin 1.5% infusion to be recommended for the treatment of patients with acute gastro-intestinal infections.