Correlation between serum free fatty acid level and estimated glomerular filtration rate in type 2 diabetic patients

• Published in: Zhong hua yi xue za zhi Vol. 96; no. 17; p. 1320
• Main Authors: Xuan, Liping, Zheng, Fenping, Lin, Xihua, Zhu, Weifen, Yin, Xueyao, Li, Hong
• Format: Journal Article
• Language: Chinese
• Published: China 10.05.2016
• Subjects: Albuminuria; Body Mass Index; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Glomerular Filtration Rate; Humans; Hypertension; Retrospective Studies; Risk Factors; Triglycerides; Uric Acid
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2016.17.004

To investigate the relationship between serum free fatty acid (FFA) level and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus (T2DM). A total of 442 T2DM patients treated in Sir Run Run Shaw Hospital from January 2013 to June 2015 were retrospectively analyzed and divided into three groups according to estimated glomerular filtration rate (eGFR) levels using modified modification of diet in renal disease (MDRD) formula: eGFR≥90 ml·min(-1)·1.73 m(-2)group (group A, 227 cases), 60 ml·min(-1)·1.73 m(-2)≤eGFR<90 ml·min(-1)·1.73 m(-2)group (group B, 118 cases), and eGFR<60 ml·min(-1)·1.73 m(-2)group (group C, 97 cases). In addition, 50 body mass index (BMI)-matched non-diabetic subjects were selected as control group. Fasting serum FFA level was measured in each group, and its relationship with eGFR was analyzed. FFA level in group C[(450±203)μmol/L]was significantly higher than that in group A[(326±167)μmol/L], group B[(394±184)μmol/L]and control group[(320±90)μmol/L](all P<0.05). Meanw