Progress in the role of oxidative stress in the pathogenesis of type 2 diabetes

Diabetes mellitus (DM) is characterized by hyperglycemia and disturbances of carbohydrate and fat metabolism resulted from an absolute or relative deficiency of insulin and insulin resistance. Recent studies indicate that oxidative stress may have a central role in the pathogenesis of type 2 diabete...

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Bibliographic Details
Published inSheng li hsüeh pao Vol. 65; no. 6; p. 664
Main Authors Ren, Chun-Jiu, Zhang, Yao, Cui, Wei-Zheng, Mu, Zhi-Mei
Format Journal Article
LanguageChinese
Published China 25.12.2013
Subjects
Apoptosis
Diabetes Mellitus, Type 2 - physiopathology
Humans
Insulin - physiology
Insulin Resistance
Mitochondria - pathology
NF-kappa B - metabolism
Oxidative Stress
Phosphatidylinositol 3-Kinases - metabolism
Phosphorylation
Reactive Oxygen Species - metabolism
Signal Transduction
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Summary:Diabetes mellitus (DM) is characterized by hyperglycemia and disturbances of carbohydrate and fat metabolism resulted from an absolute or relative deficiency of insulin and insulin resistance. Recent studies indicate that oxidative stress may have a central role in the pathogenesis of type 2 diabetes. Currently, the diagnosis of body oxidative stress level mainly depends on the detection of oxidative stress markers including reactive oxygen species (ROS), reactive nitrogen species (RNS) and lipid peroxide in clinical and experimental studies with methods combining physical and chemical means. The mechanism underlying oxidative stress-induced diabetes mainly may be through two ways. Firstly oxidative stress damages the normal function of islet β cells, through the destruction of mitochondrial structure and inducing apoptosis, activation of nuclear transcription factor kappa B (NF-κB) signaling pathway, causing cell inflammatory response, and reducing insulin synthesis and secretion by inhibiting pancreatic and
ISSN:0371-0874