Pharmacokinetics and pharmacodynamics of huangqin tang in febrile rats

• Published in: Yao hsüeh hsüeh pao Vol. 49; no. 10; p. 1418
• Main Authors: Li, Tao, Wang, Yi-Wei, Wang, Yan-Li, Zhang, Dong, Zhang, Hui-Hui, Chen, Li, Zhuang, Shuai-Xing, Zhou, Zhong-Ming, Yang, Wei-Peng
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2014
• Subjects: Administration, Oral; Animals; Area Under Curve; Chromatography, Liquid; Dinoprostone - blood; Drugs, Chinese Herbal - pharmacokinetics; Fever - metabolism; Flavanones - pharmacokinetics; Flavonoids - pharmacokinetics; Glucosides - pharmacokinetics; Interleukin-1beta - blood; Mass Spectrometry; Monoterpenes - pharmacokinetics; Rats; Tumor Necrosis Factor-alpha - blood

The pharmacodynamic (PD) and pharmacokinetic (PK) properties of Huangqin Tang (HQT) were investigated in yeast-induced febrile rats. Blood sample and rectal temperature data of the rats were collected at different times after single oral administration of HQT at 20 g x kg(-1). The plasma concentrati...