Relationship of age-related levels of serum sex hormones with bone mineral density decreasing rate in women

• Published in: Zhong hua yi xue za zhi Vol. 93; no. 30; p. 2359
• Main Authors: Wang, Dan-dan, Wu, Xi-yu, Liao, Er-yuan, Xie, Hui, Zhang, Hong, Luo, Xiang-hang, Sheng, Zhi-feng, Peng, Yi-qun, Yao, Xiao-hong, Wu, Xian-ping
• Format: Journal Article
• Language: Chinese
• Published: China 13.08.2013
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Bone Density; Estradiol - blood; Female; Follicle Stimulating Hormone - blood; Humans; Luteinizing Hormone - blood; Middle Aged; Young Adult
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2013.30.006

To explore the relationship between the changes of estrogen, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels and bone mineral density (BMD) decreasing rate (BDR) at different skeletal regions and examine the effects of hormones levels on BDR. An age cross-sectional study was conducted in 694 healthy adult women excluded from diseases and drugs affecting bone metabolism. Their age range was 20-80 years. The serum concentrations of FSH, LH and estradiol (E2) were measured with radioimmunoassay. And BDR was measured with a DXA fan-beam bone densitometer at various skeletal regions including lumbar spine, left hip and left forearm. The serum levels of FSH (r = -0.597 to -0.479, all P < 0.01) and LH r = -0.452 to -0.283, all P < 0.01) were significantly negatively correlated with BDR at various skeletal regions. Meanwhile, the serum level of E2 only had slightly positive correlation with hip and distal forearm (r = 0.077 to 0.122, all P < 0.05). After adjusting age and body mass index (BMI),