The effective mutation of epidermal growth factor receptor in synchronous multiple primary lung cancers: study of clinical, radiographic and pathological factors

• Published in: Zhong hua yi xue za zhi Vol. 99; no. 29; p. 2297
• Main Authors: Wang, Y J, Feng, H, Ma, S R, Wang, Y C, Liu, Y Y, Bai, H J, Zhao, L
• Format: Journal Article
• Language: Chinese
• Published: China 06.08.2019
• Subjects: Mutation; Receptor, epidermal growth factor; Tomography, X-ray computed; Neoplasms, multiple primary; Lung neoplasms
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2019.29.010

To investigate the clinical, pathological and CT features associated with the effective mutation of epidermal growth factor receptor (EGFR) in multiple primary lung cancers (MPLCs) , and to determine the target population of EGFR mutations tests. A total of 558 nodules from 232 patients with MPLCs who underwent surgery in the Cancer Hospital of Chinese Academy of Medical Sciences from August 2017 to December 2017 were selected. Two hundreds and sixteen nodules were detected by DNA direct sequencing. test and Mann-Whitney test were used to compare the clinical, pathological and CT features of 216 nodules in the EGFR effective mutation group and the non-effective mutation group. Logistic regression analysis was used to explore the independent risk factors of EGFR mutation. The cut off value was determined using the receiver operating characteristic(ROC) curve. Of 232 cases 558 nodules of surgically resected MPLCs, EGFR mutation of 216 nodules was determined by direct DNA sequencing. There were 58 males and 174