Research Progress in the Core Proteins of the Classical Swine Fever Virus

The core protein (CP) of the classical swine fever virus (CSFV) is one of its structural proteins. Apart from forming the nucleocapsid to protect internal viral genomic RNA, this protein is involved in transcriptional regulation. Also, during viral infection, the CP is involved in interactions with...

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Published inBingdu xuebao Vol. 31; no. 5; p. 579
Main Authors Hou, Yuzhen, Zhao, Dantong, Liu, Guoying, He, Fan, Liu, Bin, Fu, Shaoyin, Hao, Yongqing, Zhang, Wenguang
Format Journal Article
LanguageChinese
Published China 01.09.2015
Subjects
Animals
Classical Swine Fever - virology
Classical swine fever virus - genetics
Classical swine fever virus - metabolism
Classical swine fever virus - pathogenicity
Genome, Viral
Swine
Viral Core Proteins - chemistry
Viral Core Proteins - genetics
Viral Core Proteins - metabolism
Virulence
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Summary:The core protein (CP) of the classical swine fever virus (CSFV) is one of its structural proteins. Apart from forming the nucleocapsid to protect internal viral genomic RNA, this protein is involved in transcriptional regulation. Also, during viral infection, the CP is involved in interactions with many host proteins. In this review, we combine study of this protein with its disorders, structural/functional characteristics, as well as its interactions with the non-structural proteins NS3, NS5B and host proteins such as SUMO-1, UBC9, OS9 and IQGAP1. We also summarize the important part played by the CP in CSFV pathogenicity, virulence and replication of genomic RNA. We also provide guidelines for further studies in the CP of the CSFV.
ISSN:1000-8721