Effect of Yangxue Qingnao Granule on the Expression of CD11b in CA1 Region of Hippocampus of Vascular Dementia Rats

• Published in: Zhongguo Zhong xi yi jie he za zhi Vol. 36; no. 5; p. 619
• Main Authors: Li, Jing, Ma, Yuan-yuan, Liu, Bin, Mao, Wen-jing, Zhang, Jin-xia, Li, Shi-ying
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2016
• Subjects: Animals; CA1 Region, Hippocampal - drug effects; CA1 Region, Hippocampal - metabolism; CD11b Antigen - metabolism; Dementia, Vascular - drug therapy; Disease Models, Animal; Drugs, Chinese Herbal - pharmacology; Microglia - drug effects; Random Allocation; Rats; Rats, Sprague-Dawley
• ISSN: 1003-5370

To observe the effect of Yangxue Qingnao Granule (YQG) on the expression of CD11b in CA1 region of hippocampus of vascular dementia rats, and to explore its regulation on microglias. Totally 144 SD rats were randomly divided into the sham-operation group, the vascular dementia model group (model), and the YQG treated group (treated). The vascular dementia rat model was prepared by modified Pulsinelli's four-vessel occlusion. Rats in the sham-operation group and the model group were administered with normal saline -(at the daily dose of 10 mL/kg) by gastrogavage, while those in the treated group were administered with YQG (0.32 g/mL, at the daily dose of 10 mL/kg) by gastrogavage. All administration was performed once per day for 8 successive weeks. The expression of CD11b in CA1 region of hippocampus of vascular dementia rats was detected at week 1, 2, 4, and 8, respectively. Compared with the sham-operation group, the expression of CD11b in CA1 region of hippocampus of vascular dementia rats were significant