Etiology of acute pyelonephritis: species composition and populational levels of urine microflora

Acute urinary tract infection is considered to be a growing burden in both medical and socio-economic terms. The exact etiologic structure of acute pyelonephritis pathogens, their role and interference is unclear. Thus, we aimed on revealing the species composition and populational levels of microor...

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Published inGeorgian medical news no. 218; p. 44
Main Authors Stepan, V T, Fedoruk, O S, Sidorchuk, L P, Vozniuk, V V, Sidorchuk, R I
Format Journal Article
LanguageEnglish
Published Georgia (Republic) 01.05.2013
Subjects
Adult
Enterobacteriaceae - isolation & purification
Enterobacteriaceae - pathogenicity
Escherichia coli - isolation & purification
Escherichia coli - pathogenicity
Female
Humans
Male
Microbiota
Pyelonephritis - microbiology
Pyelonephritis - pathology
Pyelonephritis - urine
Staphylococcal Infections - microbiology
Staphylococcal Infections - pathology
Staphylococcal Infections - urine
Staphylococcus aureus - isolation & purification
Staphylococcus aureus - pathogenicity
Urinary Tract Infections - microbiology
Urinary Tract Infections - pathology
Urinary Tract Infections - urine
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Summary:Acute urinary tract infection is considered to be a growing burden in both medical and socio-economic terms. The exact etiologic structure of acute pyelonephritis pathogens, their role and interference is unclear. Thus, we aimed on revealing the species composition and populational levels of microorganisms causing acute inflammation of kidney and perirenal tissues. The study included 145 patients with acute pyelonephritis (mean age 34.15±6.79); 67 (47.2%) male and 78 (53.8%) female. Microbiota was defined in three different portions (samples) of urine taken during on urination. Species were considered as dominant when constancy index was 50.0% or higher, additional - from 25.0% to 50.0% and random species if value less than 25.0%. Received data expectedly correlates with other studies. Conditionally pathogenic Enterobacteriaceae play major role in etiology of acute pyelonephritis. Our study provides further evidence of higher etiologic significance of conditionally pathogenic flora (normal E. coli) over of the traditional pathogenic microorganisms like enteropathogenic Escherichia and Staphylococcus aureus.
ISSN:1512-0112