Pathological Complete Response following Neoadjuvant Chemotherapy for Locally Advanced Lower Rectal Cancer-A Case Report

A 56-year-old man was referred to our institution with bloody stools. Colonoscopy revealed a type 3 tumor in the lower rectum. Histological analysis revealed moderately differentiated adenocarcinoma. Magnetic resonance imaging indicated that the tumor was confined to the rectal wall; however, enlarg...

Full description

Saved in:
Bibliographic Details
Published inGan to kagaku ryoho Vol. 51; no. 13; p. 1363
Main Authors Nomura, Tomonori, Osawa, Hideki, Yoshioka, Shinichi, Uemura, Kohei, Okauchi, Yoshitaka, Maruyama, Minami, Ikeda, Yuji, Maruyama, Daiki, Ikeshima, Ryo, Taniguchi, Yoshiki, Asukai, Kei, Masuzawa, Toru, Fujita, Junya, Tamura, Shigeyuki, Sasaki, Yo
Format Journal Article
LanguageJapanese
Published Japan 01.12.2024
Subjects
Adenocarcinoma - drug therapy
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Capecitabine - administration & dosage
Humans
Male
Middle Aged
Neoadjuvant Therapy
Oxaliplatin - administration & dosage
Rectal Neoplasms - drug therapy
Rectal Neoplasms - pathology
Rectal Neoplasms - surgery
Online AccessGet more information

Cover

More Information
Summary:A 56-year-old man was referred to our institution with bloody stools. Colonoscopy revealed a type 3 tumor in the lower rectum. Histological analysis revealed moderately differentiated adenocarcinoma. Magnetic resonance imaging indicated that the tumor was confined to the rectal wall; however, enlarged lymph nodes were observed. Computed tomography revealed no signs of metastasis. The patient was diagnosed with rectal cancer(cT3N1aM0, cStage Ⅲb). The patient received neoadjuvant chemotherapy(NAC)consisting of capecitabine and oxaliplatin(CAPOX). After 4 courses of CAPOX, the diagnosis was revised to ycT2N0M0. The patient subsequently underwent robot-assisted intersphincteric resection, ileostomy, and bilateral lymphadenectomy. Pathological examination revealed a complete response. This case suggests that NAC may be a viable option for treating locally advanced rectal cancer.
ISSN:0385-0684