Effect of continuous hemofiltration on inflammatory mediators and hemodynamics in children with severe hand, foot and mouth disease

• Published in: Zhongguo dang dai er ke za zhi Vol. 18; no. 3; pp. 219 - 223
• Main Authors: Cao, Li-Jing, Geng, Wen-Jin, Xu, Mei-Xian, Huo, Xi-Min, Wang, Xiao-Dong, Shi, Xiao-Na
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2016
• Subjects: Child, Preschool; Cytokines - blood; Female; Hand, Foot and Mouth Disease - immunology; Hand, Foot and Mouth Disease - physiopathology; Hand, Foot and Mouth Disease - therapy; Hemodynamics; Hemofiltration; Humans; Infant; Inflammation Mediators - blood; Male; Ventricular Function, Left
• ISSN: 1008-8830
• DOI: 10.7499/j.issn.1008-8830.2016.03.006

To investigate the effect of continuous veno-venous hemofiltration (CVVH) on inflammatory mediators in children with severe hand, foot and mouth disease (HFMD), and to investigate its clinical efficacy. A total of 36 children with stage IV HFMD were enrolled and randomly divided into conventional treatment group and CVVH group (n=18 each). The children in the CVVH group were given CVVH for 48 hours in addition to the conventional treatment. The levels of interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and lactic acid in peripheral venous blood, heart rate, blood pressure, and left ventricular ejection fraction were measured before treatment and after 24 and 48 hours of treatment. After 24 hours of treatment, the conventional treatment group had a significantly reduced serum IL-2 level (P<0.01), and the CVVH treatment group had significantly reduced serum levels of IL-2, IL-6, IL-10, and TNF-α (P<0.05). After 48 hours of treatment, both groups had significant