An Elderly Patient with Local Recurrence of Gastric Cancer Responding Completely to S-1 Monotherapy

An 80-year-old man with a local recurrence of gastric cancer was treated with S-1 monotherapy leading to a complete response(CR).The patient was diagnosed with gastric cancer and underwent a distal gastrectomy with lymph node dissection. Pathological findings showed tub2>por1, pT3 (SS), pN2, pSta...

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Published inGan to kagaku ryoho Vol. 43; no. 2; p. 247
Main Authors Kusama, Toshiyuki, Yamagami, Kazuhiko, Hasegawa, Minoru, Sone, Naohiko, Kokado, Yujiro, Koshiba, Takatomo, Ichikawa, Kazuhito
Format Journal Article
LanguageJapanese
Published Japan 01.02.2016
Subjects
Aged, 80 and over
Antimetabolites, Antineoplastic - therapeutic use
Drug Combinations
Gastrectomy
Humans
Lymphatic Metastasis
Male
Neoplasm Invasiveness
Neoplasm Staging
Oxonic Acid - therapeutic use
Recurrence
Remission Induction
Stomach Neoplasms - drug therapy
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Tegafur - therapeutic use
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Summary:An 80-year-old man with a local recurrence of gastric cancer was treated with S-1 monotherapy leading to a complete response(CR).The patient was diagnosed with gastric cancer and underwent a distal gastrectomy with lymph node dissection. Pathological findings showed tub2>por1, pT3 (SS), pN2, pStage III A.Five months after surgery, the patient presented with redness of the abdominal skin.Computed tomography (CT) revealed massive tumors in the abdominal cavity with invasion to the abdominal wall. He was administered S-1, 80 mg/body/day for 14 days, followed by a 7-day rest.After 2 courses of treatment, CT showed a dramatic reduction of the tumors. After 6 months, the tumor tissue completely disappeared and he had a CR.Administration of S-1 was continued for 2 years and 6 months.There was no relapse for 3 years after discontinuation.S -1 monotherapy appears to be a feasible and effective therapy for elderly patients with recurrent gastric cancer.
ISSN:0385-0684