Effectiveness and Safety of Oral Midazolam Combined Nitrous Oxide Sedation in Treating Children with Dental Fear

• Published in: Zhōngguó yīxué kēxuéyuàn xuébào Vol. 41; no. 1; p. 106
• Main Authors: Ma, Lin, Zhang, Jie, Hou, Xue Ying, Jing, Quan, Wan, Kuo
• Format: Journal Article
• Language: Chinese
• Published: China 28.02.2019
• Subjects: Administration, Oral; Anesthesia, Dental; Child; Child, Preschool; Conscious Sedation; Cross-Over Studies; Dental Anxiety; Humans; Hypnotics and Sedatives; Midazolam - therapeutic use; Nitrous Oxide
• ISSN: 1000-503X
• DOI: 10.3881/j.issn.1000-503X.10391

Objective To evaluate the safety and effectiveness of oral midazolam sedation combined nitrous oxide sedation for reducing dental fear in children.Methods Totally 77 children with a Frankl's Behavior Rating Scale score of 1 were included in this study,among whom 41 received a total of 78 person-times of oral midazolam sedation (0.50-0.75 mg·kg ) (midazolam group) and 36 children were treated with the combination of 0.4 mg/kg oral midazolam with 30%-40% nitrous oxide (totally 73 person-times)(combination group). At each visit,heart rate,arterial oxygen saturation,and treatments were recorded. The behaviors of children during the treatment were assessed by Frankl's Behavior Rating Scale,the completion of treatment was assessed by Houpt Scale,and the sedation status was assessed by Ramsay Scale. Telephone follow-up was performed to record the side effects 24 hours after treatment. Results The vital signs were stable among all the 77 subjects,with a Ramsay score of 2 or 3. In the midazolam group, the behaviors we