A Case of Portal Vein Thrombosis Found during Postoperative Adjuvant Chemotherapy(CAPOX)after Laparoscopic Surgery for Rectal Cancer

Portal vein thrombosis after laparoscopic colorectal cancer surgery is rare and sometimes lethal. We report a case of asymptomatic portal vein thrombosis found during postoperative adjuvant chemotherapy(CAPOX)after laparoscopic surgery for rectal cancer. A male patient in his 60s underwent postopera...

Full description

Saved in:
Bibliographic Details
Published inGan to kagaku ryoho Vol. 48; no. 13; p. 1767
Main Authors Shingai, Tatsushi, Fukuzaki, Takayuki, Kato, Junichiro, Nakano, Yusuke, Taniguchi, Yoshiki, Fukata, Tadafumi, Nishida, Hisashi, Taniguchi, Hirokazu, Yoshioka, Setsuko, Hojo, Shigeyuki, Ohigashi, Hiroaki
Format Journal Article
LanguageJapanese
Published Japan 01.12.2021
Subjects
Chemotherapy, Adjuvant - adverse effects
Humans
Laparoscopy
Liver Neoplasms - drug therapy
Liver Neoplasms - surgery
Male
Portal Vein
Rectal Neoplasms - drug therapy
Rectal Neoplasms - surgery
Thrombosis - surgery
Online AccessGet more information

Cover

More Information
Summary:Portal vein thrombosis after laparoscopic colorectal cancer surgery is rare and sometimes lethal. We report a case of asymptomatic portal vein thrombosis found during postoperative adjuvant chemotherapy(CAPOX)after laparoscopic surgery for rectal cancer. A male patient in his 60s underwent postoperative adjuvant chemotherapy( CAPOX). The elevation of liver enzyme before the chemotherapy was moderate enough to start. The liver enzyme was increased mildly during the chemotherapy. Computed tomography 27 weeks after the operation revealed the thrombus from the main portal vein to the right branch and posterior branch, and atrophy of the lateral segment with narrowed left branch. Blood flow was confirmed to be maintained by ultrasonic Doppler. We decided to discontinue the chemotherapy and started anticoagulant therapy with Warfarin. Thrombosis was disappeared 2 weeks later, and liver function went back to normal range after 8 weeks. Liver dysfunction during chemotherapy should be noted not only for drug-induced liver damage, but also for the possibility of postoperative asymptomatic portal vein thrombosis.
ISSN:0385-0684