A Case of HER2-Positive Inflammatory Breast Cancer for Which Preoperative Chemotherapy with Pertuzumab Resulted in a Pathological Complete Response

A 52-year-old woman presented with redness and swelling with a peau d'orange appearance in the whole right breast. Ultrasound revealed elevated subcutaneus fat density and a diffuse hypoechoic area. She was diagnosed with inflammatory breast cancer(T4dN2M0, Stage III B of the HER2 subtype). Aft...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 43; no. 9; p. 1101
Main Authors Konishi, Naomi, Iwanaga, Takao, Ishino, Yoshito, Sugisawa, Aya, Ide, Shozo, Kimura, Hiroko, Iwata, Takashi, Watanabe, Hideki, Yokoe, Takeshi, Ojima, Eiki, Ito, Hideki, Ikeda, Tetsuya, Tonouchi, Hitoshi, Shigemori, Chika
Format Journal Article
LanguageJapanese
Published Japan 01.09.2016
Subjects
Antibodies, Monoclonal, Humanized - therapeutic use
Biopsy
Female
Humans
Inflammatory Breast Neoplasms - chemistry
Inflammatory Breast Neoplasms - drug therapy
Inflammatory Breast Neoplasms - pathology
Inflammatory Breast Neoplasms - surgery
Mastectomy
Middle Aged
Neoadjuvant Therapy
Neoplasm Staging
Receptor, ErbB-2 - analysis
Receptor, ErbB-2 - metabolism
Treatment Outcome
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Summary:A 52-year-old woman presented with redness and swelling with a peau d'orange appearance in the whole right breast. Ultrasound revealed elevated subcutaneus fat density and a diffuse hypoechoic area. She was diagnosed with inflammatory breast cancer(T4dN2M0, Stage III B of the HER2 subtype). After 4 courses of EC treatment as primary systemic therapy, the hypoechoic area was still present. Subsequent chemotherapy with pertuzumab, trastuzumab, and docetaxel was effective, as hypoechoic area was not observed on ultrasound. She underwent mastectomy and axillary dissection, and pathological examination revealed pCR. At present, 2 years after surgery, the patient is alive with no reccurence.
ISSN:0385-0684