The role of HPV genotyping testing in follow-up of high grade squamous intraepithelial lesion after treatment

To assess the clinical value of HPV genotyping in follow-up after treatment for cervical high grade squamous intraepithelial lesion (HSIL). Two hundred and thirty eight patients with HSIL receiving conization in Cancer Hospital, Chinese Academy of Medical Sciences from Dec, 2006 to Jan, 2009 were ac...

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Published inChung-hua fu chʿan kʿo tsa chih Vol. 50; no. 4; p. 258
Main Authors Li, Ning, Zuo, Jing, Huang, Ying, An, Jusheng, Yao, Hongwen, Li, Xiaoguang, Zhang, Rong, Li, Bin, Zhang, Xun, Guo, Huiqin, Wu, Lingying
Format Journal Article
LanguageChinese
Published China 01.04.2015
Subjects
Cervical Intraepithelial Neoplasia - pathology
Cervical Intraepithelial Neoplasia - surgery
Cervical Intraepithelial Neoplasia - virology
Conization
Female
Follow-Up Studies
Genotype
Human papillomavirus 16 - genetics
Human papillomavirus 16 - isolation & purification
Humans
Neoplasm Recurrence, Local - pathology
Neoplasm, Residual
Papanicolaou Test
Papillomaviridae - genetics
Papillomavirus Infections - complications
Papillomavirus Infections - diagnosis
Prospective Studies
Sensitivity and Specificity
Squamous Intraepithelial Lesions of the Cervix - surgery
Uterine Cervical Neoplasms - surgery
Vaginal Smears
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Summary:To assess the clinical value of HPV genotyping in follow-up after treatment for cervical high grade squamous intraepithelial lesion (HSIL). Two hundred and thirty eight patients with HSIL receiving conization in Cancer Hospital, Chinese Academy of Medical Sciences from Dec, 2006 to Jan, 2009 were accrued in our study. All the patients were prospectively observed after conization every 6 months for 3 times or till histologically confirmed recurrence. The items in every visit included pelvic examination, cervical cytology and HPV genotyping. Twenty-one HPV genotypes were detected by PCR-hybridization method. The last follow-up was July 31, 2010, and the median follow-up time was 28.3 months (range 6.5-43.0 months). Kaplan-Meire method as used for analyzed the median recurrent time, and the relationships between HPV status and recurrent disease were calculated by and log-rank test and Cox-regression model. Among the 238 patients, 110 cases (46.2%, 110/238) had positive result of HPV DNA testing at any visit. The
ISSN:0529-567X