Micro-CT evaluating inhibitory effect of zoledronic acid on polyethylene particle-induced periprosthetic osteolysis model

• Published in: Zhongguo gu shang Vol. 30; no. 12; p. 1107
• Main Authors: Wu, Lian-Guo, Wu, Feng-Qing, Chen, Hua
• Format: Journal Article
• Language: Chinese
• Published: China 25.12.2017
• Subjects: Animals; Bone Density; Bone Density Conservation Agents - therapeutic use; Diphosphonates - therapeutic use; Imidazoles - therapeutic use; Male; Osteolysis - etiology; Osteolysis - prevention & control; Polyethylene - adverse effects; Random Allocation; Rats; Rats, Sprague-Dawley; X-Ray Microtomography; Osteolysis; Bioprosthesis; Models, biological
• ISSN: 1003-0034
• DOI: 10.3969/j.issn.1003-0034.2017.12.007

To observe inhibitory effect of zoledronic acid on polyethylene particle-induced periprosthetic osteolysis model. Thirty male adult specific-pathogen-free SD rats (weighted 250 to 300 g) were randomly divided into sham group, model group, and zoledronic acid group, 10 in each group. Modeling were building by titanium screws and polyethylene particles implanted into right femur of rats, sham group and model group were performed hypodermic injection by 0.9% saline with 2 ml/kg, zoledronic acid with 0.1 ml/mg were injected into zoledronic acid group, once a week for 8 weeks. After 8 weeks, right femur specimens were drawn and used to san microstructure of femoral cancellous bone in rats model was examined by Micro-CT, and the images were treated with three-dimension reconstruction and analysis software BMD, BV/TV, Tb.N, Tb.Th, SMI, BS/BV, Tb.Sp and Tb.Pf and other parameters include. According to Micro-CT three-dimensional imaging, BMD in model group was significantly decreased than sham group, bone microstructu