Effects of dexmedetomidine preconditioning attenuating remote lung injury of lower limb ischemia-reperfusion

To investigate the effects of dexmedetomidine preconditioning attenuating remote lung injury of lower limb ischemia-reperfusion. Sixty patients form Central Hospital of Cangzhou scheduled for lower limb operation with tourniquet from January 2014 to June 2014. Lumbar plexus combined with sciatic ner...

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Published inZhong hua yi xue za zhi Vol. 94; no. 44; p. 3510
Main Authors Yu, Jian, Li, Rui, Yao, Wenyu
Format Journal Article
LanguageChinese
Published China 02.12.2014
Subjects
Dexmedetomidine
Humans
Interleukin-6
Interleukin-8
Lower Extremity
Lung Injury
Reperfusion Injury
Tourniquets
Tumor Necrosis Factor-alpha
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Summary:To investigate the effects of dexmedetomidine preconditioning attenuating remote lung injury of lower limb ischemia-reperfusion. Sixty patients form Central Hospital of Cangzhou scheduled for lower limb operation with tourniquet from January 2014 to June 2014. Lumbar plexus combined with sciatic nerve block was performed guided by a nerve stimulator in both groups. All patients were randomly assigned to two groups, conventional general anesthesia group (R group, n = 30) and dexmedetomidine preconditioning group (Pre-Dex group, n = 30). In the group Pre-Dex, a dexmedetomidine intravenous infusion was started at a dose of 0.125 ml/kg (4 µg/ml) for 10 minutes before using tourniquet, whereas group R received an equivalent volume of normal saline. Blood samples were taken in femoral vein for 4 ml. Monocytes TLR4 expression and interleukin-6(IL-6), interleukin-8(IL-8), tumor necrosis factor-α(TNF-α) level were determinated 15 minute before tourniquet inflation(T(1)), 15 minute (T(2)), 2 h(T(3)), 6 h(T(4))and 24 h(
ISSN:0376-2491