Significance of magnetic resonance imaging in the detection of iron overload

• Published in: Zhong hua yi xue za zhi Vol. 93; no. 44; p. 3506
• Main Authors: Zhang, Qian, Hou, Bo, Wang, Lu, Wang, Xiao-ying, Feng, Feng, Jiang, Bin, Shi, Hong-xia, Ma, Yi-gai, Liu, Hui, Han, Bing, Zhao, Yong-qiang
• Format: Journal Article
• Language: Chinese
• Published: China 26.11.2013
• Subjects: Adolescent; Adult; Aged; Female; Humans; Iron Overload - diagnosis; Magnetic Resonance Imaging; Male; Middle Aged; Young Adult
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2013.44.005

To evaluate the significance of magnetic resonance imaging (MRI) T2(*) value analysis in patients with iron overload and compare it with other clinical parameters. A total of 53 patients with suspected iron overload were recruited from four Beijing hospitals from December 2010 to December 2012. Their liver and heart T2(*) values were calculated and their serum ferritin (SF), transferrin saturation, blood transfusion volume and other clinical parameters were recorded and analyzed. There were 37 males and 16 females with a medium age of 50 years(15-72 years). Their etiologies included myelodysplastic syndromes (MDS, n = 25), aplastic anemia (AA, n = 16), myelofibrosis (n = 5), hemochromatosis (n = 2) and β thalassaemia (n = 2), and 3 patients with high SF values were found on regular health examinations. Among them, there were transfusion history (n = 45), SF>1000 µg/L (n = 49), sign of iron overload (n = 10), abnormal liver function (n = 38) and hyperglycemia (n = 32). T2(*) value analysis showed that 10 patie