Mechanism of MBL inhibiting the LPS-induced DC maturation

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 21; no. 3; p. 770
• Main Authors: Wang, Fan-Ping, Wang, Ming-Yong, Guo, Xiao-Fang, Shi, Ru-Ling, Xu, Su-Ling, Ma, Shu-Jun, Li, Hai-Bin, Guo, Ji-Qiang, Yang, Xiu-Li
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2013
• Subjects: Cell Differentiation; Cells, Cultured; Dendritic Cells - cytology; Dendritic Cells - drug effects; Dendritic Cells - metabolism; Humans; Ligands; Lipopolysaccharides - adverse effects; Mannose-Binding Lectin - pharmacology; Monocytes - cytology; Monocytes - metabolism; Toll-Like Receptor 4 - metabolism

The study was aimed to investigate the mechanism of mannan-binding lectin (MBL) on bacterial lipopolysaccharide (LPS)-induced human peripheral blood monocyte-derived dendritic cell (DC) maturation. The monocytes were prepared from the peripheral blood of healthy adult volunteers. The immature dendri...