Study on the risk factors related vertical transmission of HBV positive couples to their infant

• Published in: Zhōnghuá liúxíngbìng zázhì Vol. 33; no. 12; p. 1283
• Main Authors: Zhang, Rong-lian, Wang, Mei-ying, Chen, Qi-yan, Xiu, Xiao-yan, Ren, Kun-hai, Qiu, Li-yin, Huang, Xin-xin
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2012
• Subjects: DNA, Viral - blood; Female; Hepatitis B - transmission; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Maternal Exposure; Paternal Exposure; Pregnancy; Pregnancy Complications, Infectious - virology; Risk Factors; Viral Load
• ISSN: 0254-6450

To explore the risk factors and the rate of HBV vertical transmission from HBsAg-positive couple to their infant. 46 families who had antenatal examination at Fujian Provincial Maternal and Child Health Hospital during August 2010 and November 2011 were chosen as research object. Cord blood was sampled after delivery for HBVM and HBV-DNA quantification. Those with HBV-DNA load ≥ 5 × 10(2) copies/ml were involved in the case group while those having < 5 × 10(2) copies/ml were chosen as controls. The average positive rate of neonatal cord blood HBV-DNA was 45.7% (21/46), while the positive rates of cord blood HBsAg and HBeAg were 34.8% (16/46) and 23.9% (11/46) respectively. The positive rates of maternal serum HBV-DNA and paternal serum HBV-DNA were 52.2% (24/46) and 69.6% (32/46) respectively, with the positive rate of couple serum HBeAg as 39.1% (18/46) and 32.6% (15/46) respectively. Results from univariate analysis showed that hepatitis B surface markers, serum HBeAg-positive, serum HBV-DNA positive, and s