Expression of CD10 in tumor-associated fibroblast of cancerized or recurrent colorectal adenomas

• Published in: Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban Vol. 45; no. 4; p. 335
• Main Authors: Zheng, Jiangjiang, Zhu, Yin, Li, Changshui, Li, Yinya, Nie, Qianqian, Zhu, Ziling, Deng, Hong
• Format: Journal Article
• Language: Chinese
• Published: China 25.05.2016
• Subjects: Adenocarcinoma - chemistry; Adenocarcinoma - genetics; Adenoma - chemistry; Adenoma - genetics; beta Catenin - analysis; Biomarkers, Tumor - analysis; Cancer-Associated Fibroblasts - chemistry; Carcinogenesis - chemistry; Colorectal Neoplasms - chemistry; Colorectal Neoplasms - genetics; Cyclin D1 - analysis; Disease Progression; Humans; Immunohistochemistry; Ki-67 Antigen - analysis; Neoplasm Grading; Neoplasm Recurrence, Local - chemistry; Neprilysin - analysis; Predictive Value of Tests; Tumor Suppressor Protein p53 - analysis
• ISSN: 1008-9292

To investigate the expression of CD10 in tumor-associated fibroblasts (TAF) in colorectal adenomas and its relation to cancerization and recurrence of adenoma. Tissue samples of low-grade adenoma ( =50), high-grade adenoma ( =50) and colorectal adenocarcinoma ( =50) were collected, and tissue samples at the distal margin of corresponding colorectal lesions were taken as controls. The expression of CD10 in the stromal TAFs, and the expressions of β-catenin, Ki-67, p53 and CyclinD1 in tumor cells were detected by immunohistochemistry (Envision). The correlation of CD10 expression in stromal TAFs with the expressions of β-catenin, Ki-67, p53 and CyclinD1 in tumor cells was analyzed by Spearmen. One hundred samples of low-grade colorectal adenoma were collected, including 57 non-recurrent cases and 43 recurrent cases (16 cases of recurrent adenoma and 27 cases of recurrent adenocarcinoma); the expression of stromal TAF CD10 were determined and compared among groups. There was no TAF in normal colorectal mucosa. T