A Case of Intraductal Papillary Mucinous Adenocarcinoma with Hepatic Dysfunction Due to Tumor Perforation into the Bile Duct

• Published in: Gan to kagaku ryoho Vol. 50; no. 13; p. 1872
• Main Authors: Ishikawa, Hirosuke, Sakata, Jun, Kawachi, Yusuke, Abe, Shun, Saito, Seiji, Miura, Yohei, Ando, Takuya, Hirose, Yuki, Miura, Kohei, Takizawa, Kazuyasu, Muneoka, Yusuke, Tajima, Yosuke, Ichikawa, Hiroshi, Shimada, Yoshifumi, Wakai, Toshifumi
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.12.2023
• ISSN: 0385-0684

A 58-year-old woman presented with a complaint of weight loss. Abdominal computed tomography showed dilatation of the biliary and pancreatic ducts and a mural nodule in the pancreatic duct. The diagnosis was intraductal papillary mucinous neoplasm(IPMN). Endoscopic retrograde cholangiopancreatography(ERCP)and cholangioscopy revealed a fistula between the common bile duct and the IPMN. A sudden increase in hepatobiliary enzymes was noted preoperatively. ERCP showed that the common bile duct was obstructed by mucus. A nasobiliary drainage tube was inserted into the bile duct endoscopically and kept open by daily tube washing, and the liver dysfunction improved. Total pancreatectomy, splenectomy, and regional lymph node dissection were performed. Histological examination confirmed that the primary tumor was mixed invasive intraductal papillary mucinous adenocarcinoma. The patient remains alive and well with no evidence of recurrence 18 months after resection.