Impact of reduced left ventricular ejection fraction on all-cause mortality of 75 years old and over patients with moderate to severe aortic stenosis

• Published in: Zhōnghuá xīnxuèguănbìng zázhì Vol. 44; no. 10; p. 854
• Main Authors: Li, Z, Ye, Y Q, Wang, M Y, Xu, H Y, Teng, S Y, Qian, J, Wang, W, Wang, X, Wu, Y J
• Format: Journal Article
• Language: Chinese
• Published: China 24.10.2016
• Subjects: Aged; Aortic Valve Stenosis; Cause of Death; Echocardiography; Heart Valve Prosthesis Implantation; Humans; Regression Analysis; Retrospective Studies; Risk Factors; Stroke Volume; Treatment Outcome; Ventricular Dysfunction, Left
• ISSN: 0253-3758
• DOI: 10.3760/cma.j.issn.0253-3758.2016.10.006

To evaluate the impact of left ventricular systolic dysfunction on all-cause mortality of 75 years old and over patients with moderate to severe aortic stenosis. Clinical data of 301 consecutive aged (≥75 years old) patients with a diagnosis of non-rheumatic moderate to severe aortic stenosis by echocardiography between January 1, 2008 and January 1, 2015 in our hospital were retrospectively analyzed. According to the LVEF, patients were divided into normal LVEF subjects and low LVEF subjects, and the low LVEF level was set at below 60%(≤60%( =171)vs. >60%( =130)), 55%(≤55%( =101)vs. >55%( =200)), 50%(≤50%( =65)vs. >50%( =236)), 45%(≤45%( =51)vs. >45%( =250)) and 40%(≤40%( =37)vs. >40%( =264)), respectively. All patients were followed to January 1, 2016.The primary end point was death from any cause. Log-rank test was used to compare the mortality between groups. Multivariate Cox regression model analysis was used to identify risk factors related to all-cause death. The patients were followed-up 19 (8 to 37)