Effect of alisol A 24-acetate on proliferation of aorta smooth muscle cells in rats induced by ox-LDL

• Published in: Zhongguo zhongyao zazhi Vol. 43; no. 10; p. 2147
• Main Authors: Wei, Wei, Zhou, Xiao-Mao, Wang, Yu-Cheng, Lin, Zhi-Cheng, Xue, Ji-Hua
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2018
• Subjects: Animals; Aorta - cytology; Cell Proliferation - drug effects; Cells, Cultured; Cholestenones - pharmacology; Lipoproteins, LDL; Muscle, Smooth, Vascular - cytology; Myocytes, Smooth Muscle - cytology; Myocytes, Smooth Muscle - drug effects; Rats; cyclin; VSMC; alisol A 24-acetate; proliferation

Alisol A 24-acetate, a triterpenoid extracted from Alisma orientale, has shown anti-atherosclerotic actions and many studies have proved that oxidized low density lipoprotein (Ox-LDL) could promote proliferation of aorta smooth muscle cells (VSMCs) which are closely related to atherosclerosis (AS)....