Yinxingye Capsule Intervened Vascular Endothelial Cell Apoptosis of Hyperhomocysteinemia Rats: an Experimental Study

• Published in: Zhongguo Zhong xi yi jie he za zhi Vol. 35; no. 9; p. 1099
• Main Authors: Xu, Zhi-bing, Wang, Wei-dong, Zhang, Li-fen, Li, Jun, Wang, Yi, Xi, Xi-xiang, Zhu, Jie, Ma, Jin-miao, Jia, Jing-ying, Zhang, Li-wei, Gu, Ren-yue
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2015
• Subjects: Acetylcholine; Animals; Aorta; Aorta, Thoracic; Apoptosis - drug effects; bcl-2-Associated X Protein; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Endothelial Cells; Endothelium, Vascular; Hyperhomocysteinemia - drug therapy; Male; Nitric Oxide Synthase Type II; Nitroprusside; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar
• ISSN: 1003-5370

To explore targets of Chinese herbal medicine at cellular and molecular leve1s through an experimental study on Yinxingye Capsule (YC) intervening vascular endothelial cell apoptoeis of hyperhornocysteinemia (HHcy) rats. The HHcy model was prepared in male Wistar rats. Totally 42 rats were randomly divided into 4 groups, i.e., the control group (n =10), the model group (n = 11), the YC group (n =11), the folic acid group (n =10). Carboxy methyl cellulose (CMC) solution (1%) was administered to rats in the control group by gastrogavage.3% methionine suspension at 1. 5 g/kg was administered to rats in the model group by gastrogavage. 3% methionine suspension at 1. 5 g/kg and folic acid suspension at 0. 06 g/kg was administered to rats in the folic acid group by gastrogavage. 3% methionine suspension at 1. 5 g/kg and YC at 0. 02 g/kg was administered to rats in the YC group by gastrogavage. Morphological changes of aortic tissue were observed by hematoxylin eosin (HE) staining. The plasma homocysteine (Hcy) leve