Analysis of morphologic changes of lamina cribrosa in primary open angle glaucoma using enhanced depth imaging optical coherence tomography

• Published in: Chung-hua yen k'o tsa chih Vol. 52; no. 6; p. 422
• Main Authors: Li, L, Bian, A L, Cheng, G W, Zhou, Q
• Format: Journal Article
• Language: Chinese
• Published: China 11.06.2016
• Subjects: Analysis of Variance; Case-Control Studies; Cross-Sectional Studies; Glaucoma, Open-Angle - pathology; Humans; Middle Aged; Observer Variation; Optic Disk - pathology; Reproducibility of Results; Statistics, Nonparametric; Tomography, Optical Coherence - methods; Visual Fields
• ISSN: 0412-4081
• DOI: 10.3760/cma.j.issn.0412-4081.2016.06.006

To analyze the morphologic changes of the lamina cribrosa (LC) in primary open angle glaucoma (POAG) patients using enhanced depth imaging optical coherence tomography (EDI-OCT). This was a case-control study. Serial horizontal and vertical B-scans of the optic nerve head were obtained from one eye of 52 POAG patients and 50 age- and sex-matched healthy subjects by EDI-OCT. The number and location of focal LC defects as well as their relationship with retinal nerve fiber layer(RNFL) defects were investigated in glaucomatous eyes and compared with healthy controls. The LC thickness was measured at the center of mid-superior, central, and mid-inferior horizontal B-scans. The intra- and interobserver reproducibility were evaluated by intraclass correlation coefficient (ICC). A repeated measure ANOVA was used to analyze regional differences of the LC thickness. Independent t-test was conducted to compare LC thickness between POAG and healthy controls. A Pearson correlation was calculated for variation in LC thick