Association of methionine synthase reductase gene polymorphism with unexplained recurrent spontaneous abortion

• Published in: Chung-hua fu chʿan kʿo tsa chih Vol. 47; no. 10; p. 742
• Main Authors: Guo, Qian-nan, Liao, Shi-xiu, Kang, Bing, Zhang, Ju-xin, Wang, Rui-li, Ding, Xue-bing, Zhang, Wei-hua
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2012
• Subjects: Abortion, Habitual - genetics; Abortion, Habitual - pathology; Adult; Asian Continental Ancestry Group; Case-Control Studies; China; Female; Ferredoxin-NADP Reductase - genetics; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Pregnancy; Risk Factors; Young Adult; China
• ISSN: 0529-567X

To explore the relationship between the polymorphism of methionine synthase reductase (MTRR) A66G and the susceptibility to unexplained repeated spontaneous abortion (URSA). Total of 200 Henan Han couples with URSA (URSA group) and 76 Henan Han healthy couples without URSA (control group) were enrolled in this study. Their MTRR A66G genotypes were determined by PCR restriction fragment length polymorphism (PCR-RFLP). (1) The allele frequencies of MTRR A66G: the frequencies of allele A and allele G in URSA group were 76.5% (153/200) in husband and 72.8% (146/200) in wife, 23.5% (47/200) in husband and 27.2% (54/200) in wife, respectively. The frequencies of allele A and allele G in control group were 78.9% (60/76) in husband and 78.3% (59/76) in wife, 21.1% (16/76) in husband and 21.7% (16/76) in wife, respectively. The frequencies of allele A and allele G were not significantly different between female and male subjects within the same experimental group (P > 0.05), and also there were not significantly diffe