Low-Dose and Interval Administration of Imatinib in a Patient with Liver Metastasis of the Gastrointestinal Stromal Tumor of the Stomach - A Case Report

• Published in: Gan to kagaku ryoho Vol. 44; no. 2; p. 161
• Main Authors: Morinaga, Nobuhiro, Saito, Hideyuki, Komine, Chika, Matsumoto, Asuka, Katoh, Toshihide, Tanaka, Naritaka, Nakazato, Kenji, Nakamura, Takuro, Shitara, Yoshinori, Ishizaki, Masatoshi
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.02.2017
• Subjects: Aged; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - therapeutic use; Female; Gastrointestinal Stromal Tumors - drug therapy; Gastrointestinal Stromal Tumors - secondary; Gastrointestinal Stromal Tumors - surgery; Humans; Imatinib Mesylate - administration & dosage; Imatinib Mesylate - therapeutic use; Liver Neoplasms - drug therapy; Liver Neoplasms - secondary; Recurrence; Stomach Neoplasms - drug therapy; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Treatment Outcome
• ISSN: 0385-0684

A 69-year-old woman underwent proximal gastrectomy with distal pancreatectomy and splenectomy for a gastrointestinal stromal tumor of the stomach.Adjuvant imatinib was administered for a year.Two years after resection of the tumor, liver metastasis in S8 was detected.Therefore, imatinib was re-administered at 300mg/day.After a year of re-administration, the patient suffered muscle cramps in the hands, and therefore imatinib was administered with intervals, such as 4 weeks administration and 4 weeks rest.Re -administration of imatinib was effective and her liver metastasis decreased in size.It was not detected with CT after 1 year and 4 months and remained in complete response(CR)for 3 years and 8 months.After she suffered a brain infarction, imatinib administration was stopped for 4 months.Consequently, the liver metastasis was detectable in S8 again.This clinical course suggested that low-dose and interval administration of imatinib is effective in the treat- ment of GIST.