The Association Between Bone Morphogenic Protein-4 and in-situ Saphenous Vein Graft Pathology in Diabetic Patients Undergoing Coronary Revascularization

• Published in: Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban Vol. 47; no. 5; p. 738
• Main Authors: Zhang, Hong-Wei, Gu, Jun, Zhang, Er-Yong, Guo, Ying-Qiang, Wu, Zhong, Gan, Chang-Ping, Fan, Kang-Jun, Xiao, Zheng-Hua, Hu, Jia
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2016
• Subjects: Bone Morphogenetic Protein 4 - metabolism; Case-Control Studies; Coronary Artery Bypass; Diabetes Mellitus, Type 2 - pathology; Humans; Myocardial Revascularization; Myocytes, Smooth Muscle - metabolism; Saphenous Vein - pathology; Saphenous Vein - transplantation; Tunica Intima - pathology; Saphenous vein grafts; Bone morphogenic protein-4; Diabetes; Coronary artery bypass grafting
• ISSN: 1672-173X

This study was designed to assess the expression levels of bone morphogenic protein-4 (BMP4) in saphenous veins harvested from diabetic patients undergoing coronary artery bypass grafting (CABG), and to investigate its association with morphological and pathological changes within the venous wall. From January 2013 to December 2014, forty patients with type 2 diabetes mellitus (DM) and risk factors matched non-DM controls ( =40) were enrolled prospectively. Of the 40 DM patients, 24 had noninsulin-dependent diabetes (NIDM) and the remaining 16 had insulin-dependent diabetes (IDM). Segments of saphenous vein without surgical dilatation from these 80 patients were obtained. Vessel wall characteristics were evaluated by hematoxylin-eosin (HE) staining, and the expression and distribution of BMP4 was assessed by Western blot assay and immunohistochemistry analysis. The intimal and medial thickness of the saphenous veins harvested from DM patients were higher than those from non-DM controls. Compared with non-DM p