A Case of Nephrotic Syndrome Due to SOX plus Bmab Therapy for Liver Metastasis of Rectal Cancer

A 66-year-old man was postoperatively diagnosed with pT4a, pN2, cM1a(H2), cP0, fStage Ⅳ, RAS wild type rectal cancer. He underwent SOX plus Bmab chemotherapy 4 weeks later. After 9 courses of SOX plus Bmab, he was admitted to the hospital for leg edema and proteinuria(4+). Because of severe proteinu...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 46; no. 2; p. 288
Main Authors Murase, Hideaki, Iseki, Hideaki, Ogawa, Ayumi, Kamachi, Kenichi, Mitsuoka, Akito, Hayashi, Mikiko, Seongjin, Park, Fukuuchi, Atsushi, Kume, Shinichiro, Uriuda, Yozo, Hirayama, Kento, Negishi, Kosuke
Format Journal Article
LanguageJapanese
Published Japan 01.02.2019
Subjects
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Combined Modality Therapy
Humans
Liver Neoplasms - drug therapy
Liver Neoplasms - secondary
Male
Nephrotic Syndrome - chemically induced
Rectal Neoplasms - drug therapy
Rectal Neoplasms - pathology
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Summary:A 66-year-old man was postoperatively diagnosed with pT4a, pN2, cM1a(H2), cP0, fStage Ⅳ, RAS wild type rectal cancer. He underwent SOX plus Bmab chemotherapy 4 weeks later. After 9 courses of SOX plus Bmab, he was admitted to the hospital for leg edema and proteinuria(4+). Because of severe proteinuria(14.7 g/day)and low protein(Alb 2.0 g/dL, TP 4.9 g/dL), he was diagnosed with nephrotic syndrome. His general condition improved on stopping chemotherapy and administration of conservative treatment, and he was discharged on day 20 after admission. The proteinuria improved 3 months later. He had been undergoing SOX chemotherapy for 4 months.
ISSN:0385-0684