Effects of long term nasal continuous positive airway pressure on the blood pressure of patients with obstructive sleep apnea hypopnea syndrome

• Published in: Zhonghua jiehe he huxi zazhi Vol. 35; no. 9; p. 687
• Main Authors: Lin, Qi-chang, Deng, Chao-sheng, Ding, Hai-bo, Chen, Hua, Chen, Gong-ping, Huang, Jian-chai, Zhao, Jian-ming, Shi, Ling-yan
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2012
• Subjects: Adult; Aged; Antihypertensive Agents - therapeutic use; Blood Pressure; Continuous Positive Airway Pressure; Female; Humans; Hypertension - complications; Male; Middle Aged; Polysomnography; Sleep Apnea Syndromes - complications; Sleep Apnea Syndromes - physiopathology; Sleep Apnea Syndromes - therapy; Treatment Outcome
• ISSN: 1001-0939

To analyze the effects of long term nasal continuous positive airway pressure on the blood pressure of patients with OSAHS. From April 1997 to October 2008, 2898 patients from the First Affiliated Hospital of Fujian Medical University who complained snore during sleeping were studied. Nine hundred eighty cases were diagnosed as OSAHS with hypertension, and these patients were randomly divided into 2 groups: one group was treated with antihypertensive drugs and nasal continuous positive airway pressure (nCPAP), while the other group only received antihypertensive drugs. The polysomnography (PSG) was recorded during sleeping and the blood pressure was remeasured after 6 months or more. All patients were followed up for 5 years to observe the long-term effects of nCPAP or drugs. Systolic and diastolic blood pressure in the nCPAP group significantly decreased after 6 months [(125 ± 16) mm Hg (1 mm Hg = 0.133 kPa) vs (136 ± 19) mm Hg, (83 ± 10) mm Hg vs (95 ± 15) mm Hg, P < 0.05], and the decreasing extent of bloo