A prospective multicenter clinical trial of extralevator abdominoperineal excision for locally advanced low rectal cancer

To demonstrate the feasibility of extralevator abdominoperineal excision (ELAPE) for locally advanced low cancer in China. A prospective multicenter clinical trial was carried out by 7 general hospitals across China from August 2008 to October 2011. A total of 102 patients underwent ELAPE for primar...

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Published inChung-hua wai kʿo tsa chih Vol. 52; no. 1; p. 11
Main Authors Wang, Zhenjun, Qian, Qun, Dai, Yong, Zhang, Zhiquan, Yang, Jinshan, Li, Fei, Li, Xiaobin, Han, Jiagang, Jiang, Congqing, Jiang, Jinbo, Qi, Baoju, Liu, Zuojun, Gao, Zhigang, Du, Yanfu, Yang, Yong, Wei, Guanghui, Qu, Hao, Li, Minzhe, Ma, Huachong, Yi, Bingqiang
Format Journal Article
LanguageChinese
Published China 01.01.2014
Subjects
Adult
Aged
Digestive System Surgical Procedures - methods
Female
Humans
Male
Middle Aged
Perineum - surgery
Postoperative Complications
Prognosis
Prospective Studies
Rectal Neoplasms - surgery
Treatment Outcome
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Summary:To demonstrate the feasibility of extralevator abdominoperineal excision (ELAPE) for locally advanced low cancer in China. A prospective multicenter clinical trial was carried out by 7 general hospitals across China from August 2008 to October 2011. A total of 102 patients underwent ELAPE for primary locally advanced low rectal cancer. There were 60 male and 42 female patients. The patients' characteristics, complications and prognosis were recorded. All patients underwent the ELAPE procedure successfully. The median operating time was 180 minutes (range 110-495 minutes) and median intraoperative blood loss was 200 ml (range 50-1000 ml). The rates of sexual dysfunction, perineal complications, urinary retention, and chronic perineal pain were 40.5%, 23.5%, 18.6% and 13.7%, respectively. Chronic perineal pain was associated with coccygectomy (12 months postoperatively, t = 8.06, P < 0.01), and the pain might gradually ease over time. Reconstruction of pelvic floor with biologic mesh was associated with lower r
ISSN:0529-5815