Quantitative evaluation of inhibitory effects of epileptic spikes on theta rhythms in the network of hippocampal CA3 and entorhinal cortex in patients with temporal lobe epilepsy

Epileptic spike is an indicator of hyper-excitability and hyper-synchrony in the neural networks. The inhibitory effects of spikes on theta rhythms (4-8 Hz) might be helpful to understand the mechanism of epileptic damage on the cognitive functions. To quantitatively evaluate the inhibitory effects...

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Bibliographic Details
Published inSheng li hsüeh pao Vol. 69; no. 1; p. 77
Main Authors Ge, Man-Ling, Guo, Jun-Dan, Chen, Sheng-Hua, Zhang, Ji-Chang, Fu, Xiao-Xuan, Chen, Yu-Min
Format Journal Article
LanguageChinese
Published China 25.02.2017
Subjects
CA3 Region, Hippocampal - physiopathology
Electroencephalography
Entorhinal Cortex - physiopathology
Epilepsy, Temporal Lobe - physiopathology
Humans
Male
Theta Rhythm
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Summary:Epileptic spike is an indicator of hyper-excitability and hyper-synchrony in the neural networks. The inhibitory effects of spikes on theta rhythms (4-8 Hz) might be helpful to understand the mechanism of epileptic damage on the cognitive functions. To quantitatively evaluate the inhibitory effects of spikes on theta rhythms, intracerebral electroencephalogram (EEG) recordings with both sporadic spikes (SSs) and spike-free transient period between adjacent spikes were selected in 4 patients in the status of rapid eyes movement (REM) sleep with temporal lobe epilepsy (TLE) under the pre-surgical monitoring. The electrodes of hippocampal CA3 and entorhinal cortex (EC) were employed, since CA3 and EC built up one of key loops to investigate cognition and epilepsy. These SSs occurred only in CA3, only in EC, or in both CA3 and EC synchronously. Theta power was respectively estimated around SSs and during the spike-free transient period by Gabor wavelet transform and Hilbert transform. The intermittent extent was
ISSN:0371-0874